The article presents regression formulas for calculating the friction resistance RF and the total resistance RT of ship models in the 2.0–10.0 m range. The method for calculating the total resistance is novel and applies to the design models of an unmanned surface vessel (USV) for experimental testing of autonomous control. For both regression models (RF and RT), statistical and substantive tests were performed (the results of the calculations were compared with the experimental measurements). In both cases, convincing results were obtained, which have confirmed the possibility of their use at the preliminary design stage of unmanned ship models.