“Safe voyage from berth to berth”: This is the goal of all e-Navigation strains driven by new technologies, new infrastructures, and new organizational structures on bridge, on shore, as well as in the cloud. To facilitate these efforts suitable engineering and safety/risk assessment methods are required. Understanding maritime transportation as a sociotechnical system allows the usage of system-engineering methods. Simulation-based test beds for verification and validation (V +V) of e-Navigation technologies are important methods to obtain functional safety and reliability. The modeling and simulation toolset HAGGIS is a cosimulation system for the evaluation of e-Navigation concepts and systems. It provides a maritime traffic simulator and a physical world (n-body) simulator and services for finding rare events of failures. HAGGIS is accompanied by the physical test bed LABSKAUS, which implements a reference port and waterways. This paper describes an integrated and seamless approach for developing new e-Navigation technologies starting with virtual simulation-based safety assessment and ending in physical real-world demonstrations. It gives an overview of the actual test bed and introduces requirements, concepts and elements of HAGGIS and LABSKAUS, which are joined in the e-Maritime Integrated Reference Platform (eMIR) test bed.