The paper presents analytical and Monte Carlo simulation methods applied to the reliability evaluation of a system operating at two different operation states. A semi-Markov process is applied to construct the system operation model and its main characteristics are determined. Analytical linking of this operation model with the system reliability model is proposed to get a general reliability model of the system operating at two varying operation conditions and to find its reliability characteristics. The application of Monte Carlo simulation based on this general model to the reliability evaluation of this system is proposed as well. The results obtained from those two considered methods are evaluate